傳統(tǒng)動(dòng)物心電圖測量分析采用體表方式，雖操作簡單，但是存在測量位置影響大、測量精度不高等局限性，而心外膜表面電極測量心電圖操作極為復(fù)雜且創(chuàng)傷性大，實(shí)驗(yàn)中較少采用。為解決這一難題，Scisence 提供微創(chuàng)的多電極電生理導(dǎo)管，設(shè)計(jì)使研究者能夠?qū)ι镫娫谡麄€(gè)心臟的擴(kuò)散過程進(jìn)行更為深入的測量和分析。

電生理導(dǎo)管系統(tǒng)由八電極電生理導(dǎo)管、電極分配盒及第三方生物電放大器及刺激器組成。

工作原理：八電極電生理導(dǎo)管上的每對電極均獨(dú)立受控于電極分配盒，電極分配盒通過 2mm 針式連接線與第三方生物電放大器或刺激器相連，通過采集對應(yīng)的電極對引導(dǎo)的電信號(hào)數(shù)據(jù)。八電極電生理導(dǎo)管可用于心臟起搏，電信號(hào)記錄，進(jìn)而用于心臟電生理的各方面研究。

電生理導(dǎo)管工作原理圖

心臟電生理導(dǎo)管需要插入大鼠、小鼠等動(dòng)物的心臟內(nèi)部，測量和紀(jì)錄心房及心室的電生理信號(hào)：傳導(dǎo)時(shí)間、不應(yīng)期、希氏束電位、竇房結(jié)和房室結(jié)功能、心律失常的誘導(dǎo)。 

LabScribe 心電分析模塊

5. 可輕松提取源數(shù)據(jù)或平均數(shù)據(jù)作為圖片或文本導(dǎo)出；

6. 可選 ASCII 文本導(dǎo)入模塊將其他第三方設(shè)備采集的 ECG 數(shù)據(jù)導(dǎo)入本軟件進(jìn)行分析；

 

LabScribe 進(jìn)行心電分析

相關(guān)文獻(xiàn)：

1. Luo X, et. al. “MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation." J Clin Invest. 2013 May 1; 123(5): 1939-51
2. De Jong AM, et. al. “Atrial remodeling is directly related to end-diastolic left ventricular pressure in a mouse model of ventricular pressure overload." PLoS One. 2013 Sep 6; 8(9): e72651
3. Guasch E, et. al. “Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model." J Am Coll Cardiol. 2013 Jul 2;62(1):68-77
4. Cardin S, et. al. “Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure." Circ Arrhythm Electrophysiol. 2012 Oct; 5(5): 1027-35
5. Iwasaki YK, et. al. “Determinants of atrial fibrillation in an animal model of obesity and acute obstructive sleep apnea." Heart Rhythm. 2012 Sep; 9(9): 1409-16.e1
6. Jiao KL, et. al. “Effects of valsartan on ventricular arrhythmia induced by programmed electrical stimulation in rats with myocardial infarction." J Cell Mol Med. 2012 Jun; 16(6): 1342-51
7. Zhou Y, et. al. “Matrine inhibits pacing induced atrial fibrillation by modulating I(KM3) and I(Ca-L)." Int J Biol Sci. 2012; 8(1): 150.
8. Benito B, et. al. “Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training." Circulation. 2011 Jan 4; 123(1): 13-22
9. Prestia KA, et al. “Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice." Front Physiol. 2011 Jan 31; 2(1): 1-7
10. Aubin MC, et al. “A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia." J Appl Physiol. 2010 Feb; 108: 933-940
11. Lu Y, et al. “MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation." Circulation. 2010 Dec; 122(23): 2378-87
12. Mathur N, et al. “Sudden infant death syndrome in mice with an inherited mutation in RyR2." Circ Arrhythm Electrophysiol. 2009 Dec; 2: 677-685

     

    

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